Preferred Label : CENP-E Inhibitor GSK-923295A;
NCIt synonyms : Centromere-Associated Protein E Inhibitor GSK-923295;
NCIt related terms : GSK-923295A;
NCIt definition : A small-molecule inhibitor of the mitotic kinesin centromere-associated protein E
(CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295A
binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle
arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated
mitotic kinesin, plays an essential role in chromosome movement during mitosis and
regulates cell-cycle transition from metaphase to anaphase.;
UNII : 072702W9QD;
CAS number : 1088965-37-0;
Molecule name : GSK-923295; GSK 923295; GSK 923295A; GSK-923295A;
NCI Metathesaurus CUI : CL376164;
Origin ID : C91080;
UMLS CUI : C3491577;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
