NCIt definition : A sterile, freeze dried fraction of human plasma containing factor VIII coagulant
antigen and both the inactive and active forms of coagulation factors II (prothrombin),
VII, IX and X, with factor VIII (FVIII) inhibitor bypassing activity. Upon reconstitution
and infusion, anti-inhibitor coagulant complex is able to, either directly or indirectly,
activate thrombin, which facilitates the formation of fibrin from fibrinogen. This
results in clot formation. In hemophilic patients, antibodies formed against factor
VIII prevent factor VIII activation and impair thrombin formation; anti-inhibitor
coagulant complex can both overcome the inhibitory activity of the antibodies and
facilitate hemostasis in hemophilic patients.;
Currated CISMeF NLP mapping