" /> Pyronaridine - CISMeF





Preferred Label : Pyronaridine;

NCIt definition : A benzonaphthyridine derivative, with antimalarial and potential antiviral activities. Upon administration, pyronaridine inhibits the formation of beta-hematin, which results in the accumulation of toxic heme within the parasite. In addition, pyronaridine inhibits glutathione-dependent degradation of hematin. This promotes hematin-induced lysis of red blood cells (RBCs), resulting in parasite death. Pyronaridine also exhibits antiviral activity against some viruses in vitro, including Ebola (EBOV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viruses.;

UNII : TD3P7Q3SG6;

InChIKey : DJUFPMUQJKWIJB-UHFFFAOYSA-N;

CAS number : 74847-35-1;

Chemical formula : C29H32ClN5O2;

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31/07/2025


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