Pyronaridine - CISMeF

Preferred Label : Pyronaridine;

NCIt definition : A benzonaphthyridine derivative, with antimalarial and potential antiviral activities. Upon administration, pyronaridine inhibits the formation of beta-hematin, which results in the accumulation of toxic heme within the parasite. In addition, pyronaridine inhibits glutathione-dependent degradation of hematin. This promotes hematin-induced lysis of red blood cells (RBCs), resulting in parasite death. Pyronaridine also exhibits antiviral activity against some viruses in vitro, including Ebola (EBOV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viruses.;

UNII : TD3P7Q3SG6;

InChIKey : DJUFPMUQJKWIJB-UHFFFAOYSA-N;

CAS number : 74847-35-1;

Chemical formula : C29H32ClN5O2;

Details

Origin ID

C90737;

UMLS CUI

C0072768;

Currated CISMeF NLP mapping
- pyronaridine [MeSH concept]
- pyronaridine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pyronaridine (substance) [SNOMED CT concept]
- pyronaridine [MeSH concept]
- pyronaridine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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