Preferred Label : Beloranib;
NCIt definition : A fumagillin analogue and inhibitor of methionine aminopeptidase 2 (METAP2), with
potential antiangiogenic and anti-obesity activity. As an irreversible inhibitor,
beloranib blocks METAP2's functions, which include both protecting eukaryotic initiation
factor 2 from inhibitory phosphorylation during translation, and by removing the amino-terminal
methionine residue from nascent protein permitting the conversion of an inactive or
non-functional protein to an active one. As a result, this agent prevents endothelial
cell growth and inhibits tumor angiogenesis. In addition, METAP2 inhibition also down-regulates
ERK1/2 signaling pathway, which is usually overactive in the fat tissues of obese
people. Therefore, at a much lower dose, beloranib can induce liver fat utilization
and reduce cholesterol and fatty acid synthesis. METAP2, a member of the dimetallohydrolase
family, plays an important role during angiogenesis and is over-expressed in various
cancers.;
UNII : FI471K8BU6;
InChIKey : ZEZFKUBILQRZCK-MJSCXXSSSA-N;
CAS number : 251111-30-5;
Chemical formula : C29H41NO6;
Origin ID : C90656;
UMLS CUI : C1454350;
Automatic exact mappings (from CISMeF team)
- CKD732 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
