Preferred Label : Idarubicin-Eluting Beads;
NCIt definition : A sustained-release drug delivery embolization system containing small polymeric beads
impregnated with the anthracycline antibiotic idarubicin with potential antineoplastic
activity. The beads consist of polyvinyl alcohol (PVA) microspheres modified with
sulfonic acid groups and loaded with idarubicin. During transarterial chemoembolization
(TACE) in the hepatic artery, idarubicin-eluting beads embolize to the tumor vasculature,
occlude tumor blood vessels and induce ischemic necrosis of tumor tissue due to mechanical
blockage of the tumor vasculature. Simultaneously, idarubicin-eluting beads release
cytotoxic idarubicin locally and in a sustained manner. This may result in idarubicin-mediated
inhibition of tumor cell proliferation.;
NCI Metathesaurus CUI : CL413614;
Origin ID : C90593;
UMLS CUI : C2983790;
Semantic type(s)
- concept_is_in_subset
