Preferred Label : Brincidofovir;
NCIt synonyms : HDP-Cidofovir; 1-O-hexadecylpropanediol-CDV; Cidofovir Hexadecyloxypropyl Ester; HDP-CDV; Hexadecyloxypropyl-Cidofovir; BCV; Phosphonic Acid, p-(((1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-,
Mono(3-(hexadecyloxy)propyl) Ester;
NCIt definition : An alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate
analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol,
with antiviral activity against double-stranded DNA viruses. Upon oral administration,
brincidofovir crosses the intestinal wall and penetrates target viral-infected cells
before being cleaved to the free antiviral agent cidofovir. In turn, cidofovir is
phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate.
Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with
deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated
into the growing viral DNA strands. As a result, it prevents further DNA polymerization
and disrupts DNA replication of viruses. Compared to cidofovir, which is given intravenously,
hexadecyloxypropyl-cidofovir shows better oral bioavailability, less toxicity and
enhanced cellular penetration.;
UNII : 6794O900AX;
InChIKey : WXJFKKQWPMNTIM-VWLOTQADSA-N;
CAS number : 444805-28-1;
Molecule name : CMX001;
Chemical formula : C27H52N3O7P;
Origin ID : C90587;
UMLS CUI : C3886763;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
