Isatuximab - CISMeF

Preferred Label : Isatuximab;

NCIt synonyms : Immunoglobulin G1, Anti-(Human CD38 Antigen) (Human-mus musculus Monoclonal HU38SB19 Heavy Chain), Disulfide with Human-mus musculus Monoclonal HU38SB19 Light Chain, Dimer; Isatuximab-irfc;

NCIt definition : A humanized IgG1 monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. Isatuximab specifically binds to CD38 on CD38-positive tumor cells. This may trigger antitumoral antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and apoptosis eventually leading to cell lysis in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.;

UNII : R30772KCU0;

CAS number : 1461640-62-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1461640-62-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Sarclisa;

Molecule name : SAR-650984; Hu 38SB19; SAR 650984;

Codes from synonyms : 284;

Details

Origin ID

C90578;

UMLS CUI

C4330502;

Automatic exact mappings (from CISMeF team)
- isatuximab [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Isatuximab (substance) [SNOMED CT concept]
- Product containing isatuximab (medicinal product) [SNOMED CT concept]
- isatuximab [MeSH Supplementary Concept]
- isatuximab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 [NCIt concept]
is_component_of_chemotherapy_regimen
- Dexamethasone/Isatuximab/Pomalidomide Regimen [NCIt concept]
- Isa-Kd Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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