Preferred Label : Allogeneic IL13-Zetakine/HyTK-Expressing-Glucocorticoid Resistant Cytotoxic T Lymphocytes
GRm13Z40-2;
NCIt synonyms : GRm13Z40-2;
NCIt definition : A preparation of glucocorticoid receptor (GR) negative, allogeneic cytotoxic T-lymphocytes
(CTLs) expressing a membrane-tethered interleukin 13 (IL13) cytokine chimeric T-cell
antigen receptor (zetakine), with potential antineoplastic activity. Upon transfection
of donor T-lymphocytes with a plasmid encoding a fusion protein of the IL13-zetakine
and the selection-suicide expression enzyme HyTK, these modified CTLs are expanded
and introduced into a patient with glioblastoma multiforme (GBM). This agent specifically
targets IL13 receptor alpha2, a glioma-restricted cell-surface epitope; the CTLs exert
their cytolytic effect thereby killing IL13Ra2-expressing glioma cells. In addition,
IL13-zetakine redirected CTLs induce production of certain cytokines. Furthermore,
due to the fact that these CTLs are GR negative, they can be used concomitantly with
glucocorticoid therapy. The IL13-zetakine consists of an extracellular IL-13 E13Y
mutein-human IgG4 hinge-Fc chimera fused to human cytoplasmic CD3-zeta via the transmembrane
domain of human CD4.;
NCI Metathesaurus CUI : CL416270;
Origin ID : C90577;
UMLS CUI : C2983776;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
