Preferred Label : Autologous Melanoma Lysate/KLH-Pulsed Autologous Dendritic Cell Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with
lysate from autologous melanoma cells containing tumor associated antigens (TAAs)
and conjugated to the immunostimulant Keyhole limpet hemocyanin (KLH), with potential
immunostimulatory and antineoplastic activities. Upon administration, autologous melanoma
lysate/KLH-pulsed autologous dendritic cell vaccine may stimulate the immune system
to mount anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against
melanoma cells, which may result in melanoma cell lysis. KLH is an immunogenic carrier
and serves as an immunostimulant to improve antigenic immune recognition and T-cell
responses and can be used to evaluate vaccine efficacy.;
NCI Metathesaurus CUI : CL421240;
Origin ID : C90572;
UMLS CUI : C2983772;
Semantic type(s)
- concept_is_in_subset
