Preferred Label : HLA-A*2402-Restricted CDCA1-KIF20A Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing two HLA-A*2402-restricted peptide epitopes derived from
cancer-testis antigens with potential immunostimulatory and antitumor activities.
The peptide epitopes are derived from cell division associated 1 (CDCA1) and kinesin-like
family member 20A (KIF20A). Upon administration, HLA-A*2402-restricted CDCA1-KIF20A
multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against
CDCA1- and KIF20A-expressing tumor cells, resulting in tumor cell lysis and decreased
tumor cell proliferation. HLA-A*2402 is an MHC class I molecule that presents antigenic
peptides to CD8 T cells; epitope design restricted to epitopes that bind most efficiently
to HLA-A*2402 may improve antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL416252;
Origin ID : C90568;
UMLS CUI : C2983768;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
