Parsatuzumab - CISMeF

Preferred Label : Parsatuzumab;

NCIt synonyms : Anti-Epidermal Growth Factor-like Domain 7 Monoclonal Antibody MEGF0444A;

NCIt definition : A humanized IgG1 monoclonal antibody directed against the epidermal growth factor-like domain multiple 7 (EGFL7) with potential antineoplastic activity. Parsatuzumab binds to EGFL7, thereby preventing the activities of EGFL7 on endothelial cells and inhibiting the survival and migration of endothelial cells during angiogenesis. EGFL7, a vascular-restricted extracellular matrix protein which is upregulated during angiogenesis and which regulates vascular development, may be overexpressed on the cell surfaces of various solid tumor cell types.;

UNII : 435M4HCP2M;

CAS number : 1312797-14-0;

Molecule name : MEGF0444A; RG7414; RG 7414; MEGF 0444A;

NCI Metathesaurus CUI : CL416251;

Details

Origin ID

C90567;

UMLS CUI

C4054246;

Automatic exact mappings (from CISMeF team)
- parsatuzumab [MeSH concept]
Currated CISMeF NLP mapping
- parsatuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- parsatuzumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor-Like Protein 7 [NCIt concept]

Keyword's position in hierarchy(ies) :

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