Preferred Label : HLA-A*2402-Restricted URLC10-CDCA1-KIF20A Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing three HLA-A*2402-restricted peptide epitopes derived from
cancer-testis antigens with potential immunostimulatory and antitumor activities.
The peptide epitopes are derived from up-regulated lung cancer 10 (URLC10); cell division
cycle associated 1 (CDCA1); and kinesin-like family member 20A (KIF20A). Upon administration,
HLA-A*2402-restricted URLC10-CDCA1-KIF20A multipeptide vaccine may stimulate a cytotoxic
T lymphocyte (CTL) response against URL10-, CDCA1-, and KIF20A-expressing tumor cells,
resulting in tumor cell lysis and decreased tumor cell proliferation. HLA-A*2402 is
an MHC class I molecule that presents antigenic peptides to CD8 T cells; epitope
design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve
antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL416250;
Origin ID : C90566;
UMLS CUI : C2983766;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
