Preferred Label : Asunercept;
NCIt synonyms : CD95-Fc Fusion Protein CAN008; Fas-Fc Fusion Protein CAN008;
NCIt definition : A human, soluble fusion protein consisting of the extracellular domain of the CD95
receptor fused to the Fc-domain of the human IgG antibody, with potential antineoplastic
activity. Upon administration, asunercept binds to the CD95 ligand (CD95L) and blocks
the binding of CD95L to the CD95 receptor. In tumor cells, blockage of CD95L-mediated
signaling pathways may prevent cell migration and invasive cell growth; in healthy
cells, blockage of CD95L-mediated signaling pathways may prevent apoptosis and may
protect cell damage. Activation of the CD95 receptor plays an important role in the
initiation of apoptosis in healthy cells or the invasive growth of cancer cells.;
UNII : F333OQQ9UV;
CAS number : 1450882-18-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1450882-18-4
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G-SRS /a ;
Drug name : Apocept;
Molecule name : APG-101; CAN-008;
Origin ID : C90562;
UMLS CUI : C5139847;
Semantic type(s)
- concept_is_in_subset
