Preferred Label : Autologous TriMix-DC Melanoma Vaccine;
NCIt definition : A dendritic cell vaccine consisting of dendritic cells (DCs) electroporated with mRNA
encoding three adjuvants, CD40 ligand (CD40L), a constitutively active TLR4, and CD70
(all together termed TriMix); coelectroporated with full-length mRNA encoding MAGE-A3,
MAGE-C2, Tyrosinase and gp100; and linked to DC-LAMP, with potential immunostimulating
activity. Upon vaccination, the DCs may stimulate the immune system to mount an antigen-specific
cytotoxic T-lymphocyte (CTL) response against the melanoma antigens. This may decrease
cellular proliferation of melanoma cells expressing these antigens. Electroporation
with the adjuvants CD40L and TLR4 allows for the generation of mature and active DCs;
electroporation with CD70 provides a costimulatory signal to CD27 naive T cells thereby
supporting T-cell proliferation and inhibiting T-cell apoptosis.;
NCI Metathesaurus CUI : CL416244;
Origin ID : C90560;
UMLS CUI : C2983759;
Semantic type(s)
- concept_is_in_subset
