Preferred Label : Carbon C 14 Ombrabulin;
NCIt synonyms : [14C]-AVE8062;
NCIt definition : A synthetic water-soluble analogue of combretastatin A4, derived from the South African
willow bush (Combretum caffrum), labeled with carbon C 14 with potential antineoplastic
activity. The ombrabulin moiety of carbon C 14 ombrabulin binds to the colchicine
binding site of endothelial cell tubulin, thereby inhibiting tubulin polymerization
and inducing mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial
cells detach from their substrata, tumor blood vessels collapse; the acute disruption
of tumor blood flow may result in tumor necrosis. The radioisotope moiety of this
agent acts as a radioactive tracer.;
NCI Metathesaurus CUI : CL416240;
Origin ID : C90556;
UMLS CUI : C2983755;
Semantic type(s)
- concept_is_in_subset
