Preferred Label : CEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine;
NCIt synonyms : tetwtCEA DNA;
NCIt definition : A plasmid vaccine encoding wild type human carcinoembryonic antigen (CEA) fused to
a tetanus toxoid T helper epitope, with potential antineoplastic activity. Upon vaccination
and subsequent intradermal electroporation, CEA/tetanus toxoid T helper epitope fusion
protein-expressing DNA plasmid vaccine may stimulate the immune system to mount a
cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA, a tumor
associated antigen, is overexpressed in a variety of cancer cell types. The tetanus
toxoid helper peptide epitope, obtained from the bacterial Clostridium tetani toxoid,
binds to class II MHC molecules and increases the helper T-cell response thereby inducing
an increased and long-term immune response.;
NCI Metathesaurus CUI : CL416239;
Origin ID : C90555;
UMLS CUI : C2983754;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
