Preferred Label : Multikinase Inhibitor 4SC-203;
NCIt related terms : 4SC-203;
NCIt definition : A multikinase inhibitor with potential antineoplastic activity. Multikinase inhibitor
4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated
forms, and vascular endothelial growth factor receptors (VEGFRs). This may result
in the inhibition of angiogenesis and cell proliferation in tumor cells in which these
kinases are upregulated. FLT3 (FLK2), a class III tyrosine kinase receptor, is overexpressed
or mutated in most B lineage and acute myeloid leukemias (AML). VEGFRs, tyrosine kinase
receptors, are overexpressed in a variety of tumor cell types and play key roles in
angiogenesis.;
UNII : RFG3GJ6251;
CAS number : 895533-09-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 895533-09-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : 4SC-203;
NCI Metathesaurus CUI : CL416237;
Origin ID : C90553;
UMLS CUI : C2983752;
Semantic type(s)
- concept_is_in_subset
