Preferred Label : Anti-EGP-2 Immunotoxin MOC31-PE;
NCIt synonyms : Anti-Epithelial Glycoprotein-2 Immunotoxin MOC31-PE;
NCIt definition : An immunotoxin consisting of a monoclonal antibody directed against epithelial glycoprotein-2
(EP-2, or epithelial cell adhesion molecule (EpCAM)) conjugated to the bacterial toxin
Pseudomonas exotoxin A (PE) with potential antineoplastic activity. Upon administration
of anti-EGP-2 immunotoxin MOC31-PE, the monoclonal antibody moiety targets and binds
to EP-2. Upon internalization, the Pseudomonas exotoxin A moiety then inactivates
elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein
synthesis in EP-2-expressing cells. EP-2, a tumor-associated antigen, is overexpressed
in a variety of cancer cell types.;
Molecule name : MOC31-PE;
NCI Metathesaurus CUI : CL416235;
Origin ID : C90551;
UMLS CUI : C2983750;
Semantic type(s)
- concept_is_in_subset
