Preferred Label : Darleukin;
NCIt synonyms : L19-IL2; L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein;
NCIt definition : An immunoconjugate consisting of the recombinant form of the cytokine interleukin-2
(IL-2) fused to a human single-chain Fv (scFv) antibody fragment directed against
the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating
and antineoplastic activities. The L19 moiety of L19-IL2 monoclonal antibody-cytokine
fusion protein binds to the ED-B domain of fibronectin on tumor cells in the tumor
neovasculature. In turn, the IL-2 moiety may locally activate natural killer (NK)
cells and macrophages, and may induce T cell cytotoxic immune responses against ED-B
fibronectin-expressing tumor cells. This may specifically decrease the proliferation
of ED-B-expressing tumor cells. ED-B is predominantly expressed during angiogenesis
and tumor growth.;
UNII : 2OQ3OPV2F8;
NCI Metathesaurus CUI : CL416230;
Origin ID : C90546;
UMLS CUI : C2983744;
Semantic type(s)
- concept_is_in_subset
