Preferred Label : Fluorouracil Implant;
NCIt definition : An implant containing a sustained release particle of fluorouracil, an antimetabolite
fluoropyrimidine analog of the nucleoside pyrimidine, with antineoplastic activity.
Upon implantation and subsequent release, fluorouracil is converted into the active
metabolite 5-fluoroxyuridine monophosphate that competes with the pyrimidine uracil
during RNA synthesis while another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate,
inhibits thymidylate synthase and thus DNA synthesis.;
Drug name : Sinofuan;
NCI Metathesaurus CUI : CL416225;
Origin ID : C90544;
UMLS CUI : C2983741;
Semantic type(s)
- concept_is_in_subset
