Preferred Label : Mipicoledine;
NCIt synonyms : 4-Demethylcholesteryloxycarbonylpenclomedine; DM-CHOC-PEN;
NCIt definition : A cholesterol carbonate derivative of 4-demethylpenclomedine (DM-PEN) with potential
antineoplastic alkylating activity. Upon intravenous administration of mipicoledine,
the carbonium moiety binds to and alkylates DNA at the N7 guanine position, thereby
causing DNA crosslinks. This prevents DNA replication, inhibits cellular proliferation
and triggers apoptosis. In addition, due to its lipophilic cholesteryl moiety this
agent is able to cross the blood brain barrier (BBB) and therefore can be given intravenously
compared to other alkylating agents that need to be given intra-cranially.;
UNII : 1S83F4T2WE;
CAS number : 942149-56-6;
NCI Metathesaurus CUI : CL416220;
Origin ID : C90539;
UMLS CUI : C2983735;
Semantic type(s)
- concept_is_in_subset
