Preferred Label : Plasmid Encoding Antiangiogenic Metargidin Peptide;
NCIt synonyms : Peptide AMEP;
NCIt definition : A plasmid encoding the protein antiangiogenic metargidin plasmid (AMEP), the disintegrin
domain of ADAM-15 (metargidin), with potential antiangiogenic and antimetastatic activities.
Upon intratumoral electrotransfer of plasmid encoding AMEP, AMEP binds to cellular
integrin receptors alpha-v-beta-3 (avb3) and alpha-5-beta-1 (a5b1), which are upregulated
on activated endothelial cells and a variety of tumor cells. Binding to the integrin
receptors may inhibit angiogenesis and may inhibit tumor cell proliferation.;
Drug name : AMEP;
NCI Metathesaurus CUI : CL413626;
Origin ID : C90537;
UMLS CUI : C2983732;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
