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Protein Stabilized Liposomal Docetaxel Nanoparticles - CISMeF
Protein Stabilized Liposomal Docetaxel NanoparticlesNCIt concept
Preferred Label : Protein Stabilized Liposomal Docetaxel Nanoparticles;
NCIt definition : A formulation containing protein-stabilized liposome nanoparticles encapsulating the
poorly water-soluble, second-generation taxane analog docetaxel with antineoplastic
activity. Docetaxel binds to and stabilizes the beta-tubulin subunit, thereby inhibiting
microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell
death. This agent also inhibits pro-angiogenic factors such as vascular endothelial
growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties
by inducing various mediators of the inflammatory response. Compared to the use of
toxic carriers to increase solubilization of docetaxel, protein-stabilized liposomal
docetaxel improves drug solubility while avoiding carrier-associated toxicity.;
Semantic type(s)