Ensituximab - CISMeF

Preferred Label : Ensituximab;

NCIt synonyms : Anti-CPAA Monoclonal Antibody NPC-1C; Anti-Colorectal and Pancreatic Carcinoma-Associated Antigen Monoclonal Antibody NPC-1C;

NCIt definition : A chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Anti-CPAA monoclonal antibody NPC-1C binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. NPC-1C contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype.;

UNII : F988K568V2;

CAS number : 1092658-06-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1092658-06-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : NPC-1C;

NCI Metathesaurus CUI : CL413613;

Details

Origin ID

C90532;

UMLS CUI

C2983727;

Automatic exact mappings (from CISMeF team)
- ensituximab [MeSH concept]
Currated CISMeF NLP mapping
- ensituximab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- MUC5AC protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ensituximab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mucin-5AC [NCIt concept]

Keyword's position in hierarchy(ies) :

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