NCIt synonyms : CD156; MS2; Human Leukocyte Differentiation Antigen Gene; A Disintegrin and Metalloproteinase Domain 8 Gene; MGC134985; ADAM Metallopeptidase Domain 8 wt Allele;
NCIt definition : Human ADAM8 wild-type allele is located in the vicinity of 10q26.3 and is approximately
14 kb in length. This allele, which encodes disintegrin and metalloproteinase domain-containing
protein 8, plays a role in the regulation of proteolysis. The gene may be involved
in neurodegeneration and allergic respiratory diseases.;
NCIt note : The ADAM8 gene was shown to be essential for establishing blood flow in zebrafish
embryos. (Current Biology. 2010; 20: 1110-6.);