Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11

Preferred Label : Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11;

NCIt synonyms : Acute Myeloid Leukemia with inv(16)(p13q22)(CBFb/MYH11); Acute Myeloid Leukemia, inv(16)(p13q22); Acute Myeloid Leukemia with inv(16)(p13q22); Acute Myeloid Leukemia with inv 16 p13 q22; Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB::MYH11; Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB::MYH11 Fusion; Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11 Fusion;

NCIt related terms : Acute myeloid leukemia, inv(16)(p13;q22);

NCIt definition : Acute myeloid leukemia characterized by the presence of abnormal bone marrow eosinophils and the characteristic cytogenetic abnormality inv(16)(p13.1q22) which results in the expression of the fusion protein CBFB-MYH11.;

Neoplastic status : Malignant;

Détails

Origin ID

C9018;

UMLS CUI

C1533174;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukemia with CBFB::MYH11 fusion (morphologic abnormality) [SNOMED CT concept]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Auer Rods Present [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
- inv(16)(p13.1;q22) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Eosinophil [NCIt concept]
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Monoblast [NCIt concept]
- Neoplastic Monocyte [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Neoplastic Neutrophilic Precursor [NCIt concept]
- Neoplastic Promonocyte [NCIt concept]
disease_has_finding
- Abnormal Eosinophilic Granules Present [NCIt concept]
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Blasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Bone Marrow Eosinophilia [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Granulocytes and Precursors 20 Percent or More of Bone Marrow Cells [NCIt concept]
- Neoplastic Monocytes and Precursors 20 Percent or More of Bone Marrow Cells [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- CBFB-MYH11 Fusion Protein Expression [NCIt concept]
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Granulocyte-Monocyte Progenitor Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- CBFB Gene [NCIt concept]
- CBFB/MYH11 Fusion Gene [NCIt concept]
- MYH11 Gene [NCIt concept]

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