Preferred Label : 2-(indol-3-ylmethyl)-3,3'-diindolylmethane;
NCIt definition : The major and active metabolic product of dietary indole-3-carbinol, present in a
wide variety of plant food substances from the Cruciferae family, with cytostatic
and antiestrogenic properties. 2-(indol-3-ylmethyl)-3,3'-diindolylmethane is an antagonist
of estrogen receptor, and could inhibit the proliferation of both estrogen-dependent
and -independent breast cancer cells. In addition, this agent also activates binding
of the aryl hydrocarbon (Ah) receptor to its cognate DNA responsive element and expression
of the Ah receptor-responsive gene CYP1A1.;
Origin ID : C89855;
UMLS CUI : C0908038;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
