Preferred Label : Holliday Junction;
NCIt synonyms : Holliday Structure;
NCIt definition : A DNA structure formed between similarly oriented, homologous DNA double strands in
which a single strand from one duplex crosses over to base pair with the complimentary
strand on the other duplex, generating a cruciform structure. Such structures are
an intermediate in homologous recombination that is conserved from yeast to humans.
The branches of a Holliday junction are ordinarily resolved by cleavage of two of
the DNA strands. This yields double stranded daughter DNA duplexes with combinations
of genes that may be unique from those of the parent duplexes.;
Origin ID : C89779;
UMLS CUI : C1258072;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
