Preferred Label : Ligand-Independent Chloride Ion Channel Activation;
NCIt definition : A process that involves the detection of and alteration of either the voltage or pH
across a membrane, and results in a chloride channel becoming permeable to Cl- and
related ions, including HCO3-, I-, SCN- and NO3-. This interaction plays a crucial
role in setting the potential of the resting membrane, but also functions to regulate
pH, the transport of organic solutes and the migration, differentiation and proliferation
of cells.;
NCIt note : Deficiencies in this process may result in pathologies including Bartter Syndrome,
Dent Disease and Thomsen Disease.;
Origin ID : C88549;
UMLS CUI : C2982035;
Semantic type(s)
- biological_process_is_part_of_process
