Calcium Release-Activated Calcium Channel Protein 1

Preferred Label : Calcium Release-Activated Calcium Channel Protein 1;

NCIt synonyms : Transmembrane Protein 142A; Protein Orai-1; ORAI1;

NCIt definition : Calcium release-activated calcium channel protein 1 (301 aa, 33 kDa) is encoded by the human ORAI1 gene. This protein plays a role in both the regulation of cellular calcium concentration and the transcription of pathogen responsive genes.;

Details

Origin ID

C88519;

UMLS CUI

C1722208;

OMIM relation
- Orai calcium release-activated calcium modulator 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ORAI1 protein, human [MeSH concept]
- ORAI1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Ion Channel Protein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- ORAI1 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Ion Channel [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_malfunction_associated_with_disease
- Severe Combined Immunodeficiency [NCIt concept]
gene_product_plays_role_in_biological_process
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- T-Cell Differentiation [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Calcium Release-activated Channels Inhibitor RP4010 [NCIt concept]
- Zegocractin [NCIt concept]

Keyword's position in hierarchy(ies) :

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