Onzigolide - CISMeF

Preferred Label : Onzigolide;

NCIt synonyms : Dopamine-Somatostatin Chimeric Molecule TBR-760;

NCIt definition : A chimeric dopamine (DA)-somatostatin (SST) compound, with potential antineoplastic activity. Upon administration, onzigolide binds with high affinity to dopamine D2 receptor (D2R) and somatostatin receptor subtype 2 (SSTR2), and to a lesser extent to somatostatin receptor subtype 5 (SSTR5). This agent appears to exert its effect mainly by binding to D2R to activate the ERK1/2 and p38 MAPK pathways, thus inducing apoptosis and inhibiting cellular proliferation in non-functioning pituitary adenoma (NFPA) and neuroendocrine tumors. By binding to SSTR2, this agent may inhibit the secretion of growth hormone (GH) by the pituitary gland.;

UNII : L32IM11DV4;

CAS number : 868562-36-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 868562-36-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BIM-23A760; TBR 760; TBR-760;

Details

Origin ID

C88345;

UMLS CUI

C5557437;

Currated CISMeF NLP mapping
- BIM 23A760 [MeSH concept]
- TBR-760 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BIM 23A760 [MeSH concept]
- TBR-760 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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