Preferred Label : Fimaporfin A;
NCIt synonyms : Disulfonated Tetraphenylchlorin; TPCS2a; Tetraphenyl Chlorin Disulfonate;
NCIt definition : The A isomer of fimaporfin, a synthetic light-activated compound, with potential photosensitizing
activity. Upon administration, fimaporfin A incorporates into the cell's endosome
and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate
in endosomal and lysosomal compartments; upon local activation by light, fimaporfin
A produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal
membranes and accumulated cytotoxic agents are released into the tumor cell cytosol.
This photochemical internalization (PCI) method can enhance the efficacy and selectivity
of cytotoxic agents.;
UNII : P4BBY8S91N;
InChIKey : MVBCOYVJSZKRIV-JAAFTSFNSA-N;
CAS number : 501083-97-2;
Drug name : Amphinex;
NCI Metathesaurus CUI : CL413542;
Origin ID : C88344;
UMLS CUI : C2981862;
Semantic type(s)
- concept_is_in_subset
