Preferred Label : CpG Oligodeoxynucleotide GNKG168;
NCIt synonyms : CpG ODN GNKG168;
NCIt related terms : GNKG-168;
NCIt definition : A synthetic, 21-mer, unmethylated CpG motif-based oligodeoxynucleotide (ODN), with
immunostimulatory activity. CpG oligodeoxynucleotide GNKG168 binds to and activates
Toll-like receptor 9 (TLR9) and is taken up into cells by endocytosis; once internalized,
it may activate numerous signaling transduction pathways resulting in the release
of multiple cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins
(ILs) and tumor necrosis factor (TNF). Through activation of TLR9, this ODN can directly
stimulate B-lymphocytes, dendritic and natural killer (NK) cells, resulting in an
increase in innate immunity and antibody-dependent cellular cytotoxicity (ADCC). In
addition, through the release of IL-12 and IFN, this agent may induce a preferential
shift to the T-helper 1(Th1) phenotype resulting in enhanced CD8 T cell-mediated
antitumor cytotoxicity.;
UNII : JK03C8HWHK;
Molecule name : GNKG-168;
Origin ID : C88342;
UMLS CUI : C2981861;
Semantic type(s)
- UMLS correspondences (same concept)
- GNKG168 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
