Preferred Label : 3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine;
NCIt synonyms : Nicotine Conjugate Vaccine;
NCIt definition : A hapten-carrier immunoconjugate composed of the hapten trans-3'-aminomethyl nicotine
conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through
amino acid depletion, with potential immunostimulating activity. Upon vaccination
with 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune
system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the
blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small
organic molecule that is not immunogenic, must be haptenized and conjugated to a carrier
protein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody
response. Aluminium hydroxide may be used as an adjuvant for this vaccine.;
Drug name : NicVax;
Origin ID : C88341;
UMLS CUI : C2981859;
Semantic type(s)
- concept_is_in_subset
