Preferred Label : Topical PVDF/Sirolimus;
NCIt synonyms : Topical PVDF/Rapamycin; PVDF/Sirolimus Topical;
NCIt definition : A topical formulation consisting of a polyvinylidene fluoride (PVDF) polymer resin
containing the macrolide sirolimus (rapamycin), produced by the organism Streptomyces
hygroscopicus, with immunosuppressive activity. Upon application of topical PVDF/sirolimus,
sirolimus migrates from the PVDF polymer resin into the skin. Once inside cells, sirolimus
binds to the immunophilin FK binding protein-12 (FKBP-12) and forms a sirolimus:FKBP-12
complex. This complex binds to and inhibits the activity of the serine/threonine kinase
mammalian target of rapamycin (mTOR), which may result in the suppression of cytokine-driven
T-cell activation and proliferation.;
NCI Metathesaurus CUI : CL413605;
Origin ID : C88340;
UMLS CUI : C2981858;
Semantic type(s)
- concept_is_in_subset
