Preferred Label : Carbon C-14 Dacomitinib;
NCIt synonyms : [14C]PF-00299804; Carbon C 14 PF-00299804;
NCIt definition : A radioconjugate consisting of an orally bioavailable small-molecule inhibitor of
the epidermal growth factor receptor (erbB or HER) family of tyrosine kinases radiolabeled
with carbon-14 with potential antineoplastic and beta-emitting radioisotope activity.
PF-00299804 specifically and irreversibly binds to and inhibits human Her-1, Her-2,
and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells
that overexpress these receptors. The HER receptor family of tyrosine kinases, often
overexpressed by a variety of tumor cell types, may contribute to tumor cell proliferation,
differentiation, migration, and survival. PF-00299804 radiolabeled with carbon C-14
may be used as a radiotracer in pharmacological studies of PF-00299804 metabolism.;
NCI Metathesaurus CUI : CL413604;
Origin ID : C88339;
UMLS CUI : C3642447;
Semantic type(s)
- concept_is_in_subset
