Preferred Label : Smoothened Antagonist LDE225 Topical;
NCIt definition : A topical formulation of the small-molecule Smoothened (Smo) antagonist LDE225 with
potential antineoplastic activity. Upon topical application, smoothened antagonist
LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which
may result in the suppression of the Hh signaling pathway and, so, the inhibition
of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway
plays an important role in cellular growth, differentiation and repair. Inappropriate
activation of Hh pathway signaling and uncontrolled cellular proliferation, as is
observed in a variety of cancers, may be associated with mutations in the Hh-ligand
cell surface receptor Smo.;
Molecule name : LDE225;
NCI Metathesaurus CUI : CL413601;
Origin ID : C88337;
UMLS CUI : C2981855;
Semantic type(s)
- concept_is_in_subset
