Preferred Label : Ad5-yCD/mutTK(SR39)rep-ADP;
NCIt definition : A second generation, replication-competent adenovirus type 5 containing a yeast cytosine
deaminase(yCD)/mutant sr39 herpes simplex virus thymidine kinase fusion (yCD/mutTKsr39)
gene and the 11.6 kDa adenovirus death protein (ADP) gene with potential oncolytic
activity. Upon intratumoral administration and transduction of Ad5-yCD/mutTK(SR39)rep-ADP
into tumor cells and subsequent expression of cytosine deaminase and viral thymidine
kinase, administered prodrugs 5-fluorocytosine (5-FC) and ganciclovir are converted
into their respective metabolites 5-fluorouracil (5-FU) and ganciclovir-5-monophosphate
(ganciclovir-MP); 5-FU is subsequently metabolized to cytotoxic active metabolites
5-fluoroxyuridine monophosphate (F-UMP) and 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate
(F-dUMP); ganciclovir-TP subsequently is converted by mammalian thymidine kinase to
cytotoxic ganciclovir-triphosphate (ganciclovir -TP). Tumor cells adjacent to tumor
cells transduced with this agent may be killed through a 'bystander effect'. ADP may
enhance spread and oncolytic activity of replication-competent adenoviruses. In addition
to its oncolytic activity, Ad5-yCD/mutTK(SR39)rep-ADP may exhibit radiosensitizing
activity.;
NCI Metathesaurus CUI : CL413593;
Origin ID : C88330;
UMLS CUI : C2981847;
Semantic type(s)
- concept_is_in_subset
