Preferred Label : Tipapkinogene Sovacivec;
NCIt synonyms : MVA-HPV16E6/E7-IL2; MVA-HPV-IL2; HPV16 E6/E7-encoding MVA Vaccine TG4001;
NCIt definition : A cancer vaccine comprised of a modified, replication-defective, vaccinia virus Ankara
(MVA) strain encoding the tumor-associated antigens (TAAs) human papillomavirus type
16 (HPV16) subtypes E6 and E7, and human interleukin-2 (IL-2), with potential immunostimulating
and antineoplastic activities. Vaccination with tipapkinogene sovacivec stimulates
the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor
cells expressing HPV16 E6 and E7, resulting in tumor cell lysis. Expression of IL-2
augments the specific CTL response against HPV16 E6- and E7-expressing tumor cells.;
UNII : P34L5Y2SR5;
CAS number : 1052105-48-2;
Molecule name : RO5217790; TG 4001; R3484; RG3484; TG-4001;
NCI Metathesaurus CUI : CL413588;
Origin ID : C88326;
UMLS CUI : C4727599;
Semantic type(s)
- concept_is_in_subset
- has_target
