Preferred Label : Anti-IL-1 alpha Monoclonal Antibody MABp1;
Obsolete resource : true;
NCIt synonyms : Anti-IL1a Monoclonal Antibody; Anti-IL-1 Alpha Monoclonal Antibody;
NCIt definition : A human IgG1 monoclonal antibody directed against interleukin-1 alpha (IL1a) with
potential A human IgG1 monoclonal antibody targeting the inflammatory cytokine interleukin-1
alpha (IL1a) with potential antineoplastic, anti-cachectic and anti-angiogenic activities.
Anti-IL1a monoclonal antibody MABp1 targets and binds to IL1a and prevents IL1a activity.
This prevents IL1a-mediated tumorigenesis and angiogenesis. In addition, MABp1 abrogates
IL1a-mediated cachexia. IL1a, an inflammatory mediator expressed on monocytes, platelets
and overexpressed by certain tumors, plays a key role in the promotion of tumor cell
growth, metastasis and invasion. In addition, IL1a stimulates metabolic activity in
the central nervous system.;
NCIt note : See 'Bermekimab(C95708)';
Concept status : Retired_Concept;
Drug name : Xilonix;
Molecule name : MABp1;
Origin ID : C88325;
UMLS CUI : C2981842;
Currated CISMeF NLP mapping
- Semantic type(s)
