Preferred Label : Burixafor;
NCIt synonyms : Phosphonic Acid, p-(2-(4-(6-Amino-2-(((trans-4-(((3-(cyclohexylamino)propyl)amino)methyl)cyclohexyl)methyl)amino)-4-pyrimidinyl)-1-piperazinyl)ethyl)-;
NCIt definition : An orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor
binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the
chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1
(SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may
induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow
into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor
(GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is
upregulated in several tumor cell types; CXCL12/CXCR4 interaction induces retention
of hematopoietic cells in the bone marrow.;
UNII : 2G17Y0Q20G;
InChIKey : QLVSJMZJSABWRX-YHBQERECSA-N;
CAS number : 1191448-17-5;
Molecule name : TG-0054;
NCI Metathesaurus CUI : CL413584;
Origin ID : C88323;
UMLS CUI : C4053692;
Semantic type(s)
- concept_is_in_subset
