Preferred Label : Docetaxel Formulation CKD-810;
NCIt definition : An injectable formulation containing the taxane docetaxel, a semisynthetic analogue
of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin
subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly,
which results in cell-cycle arrest at the G2/M phase and cell death. This agent also
inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF)
and induces various mediators of the inflammatory response.;
Molecule name : CKD-810;
NCI Metathesaurus CUI : CL413582;
Origin ID : C88322;
UMLS CUI : C2981839;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
