CDC7 Kinase Inhibitor NMS-1116354

Preferred Label : CDC7 Kinase Inhibitor NMS-1116354;

NCIt definition : An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 initiates DNA replication by phosphorylating MCM2 (minichromosome maintenance complex component 2) at Ser40 and Ser53.;

Molecule name : NMS-1116354;

NCI Metathesaurus CUI : CL413571;

Details

Origin ID

C88316;

UMLS CUI

C2981831;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cell Division Cycle 7-Related Protein Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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