Preferred Label : Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes;
NCIt definition : A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to
cytomegalovirus (CMV) and adenovirus (AdV) with potential antiviral activity. Allogeneic
CMV/AdV-specific cytotoxic T lymphocytes are prepared by exposing donor-derived CTLs
to a lethally irradiated Epstein-Barr virus-positive lymphoblastoid B cell line (EBV-LCL)
that has been transduced with a clinical-grade adenoviral vector (Ad5f35CMVpp65) as
a source of CMV and AdV antigens. Infusion of these CTLs into stem cell transplant
recipients may prevent CMV and AdV viral disease.;
NCI Metathesaurus CUI : CL413565;
Origin ID : C88310;
UMLS CUI : C2981826;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
