Preferred Label : Anti-EGFRvIII Immunotoxin MR1-1;
NCIt synonyms : MR1-1KDEL; MR1scFvPE38KDEL;
NCIt definition : A recombinant immunotoxin consisting of single-chain variable domain fragment antibody
directed against the tumor-specific antigen EGFRvIII (MR1scFv) fused to domains II
and III of the Pseudomonas exotoxin (PE38KDEL), with potential antineoplastic activity.
Upon administration, the antibody moiety of anti-EGFRvIII immunotoxin MR1-1 binds
to EGFRvIII; upon internalization, the exotoxin portion inhibits protein synthesis,
resulting in a reduction in tumor cell proliferation of EGFRvIII- expressing tumor
cells. EGFRvIII, a type III in-frame deletion mutation of the epidermal growth factor
receptor (EGFR) gene, is expressed by a variety of cancers, including glioblastoma
multiforme, non-small lung carcinoma, and breast carcinoma. Compared to intact IgG
antibodies, single-chain antibodies such as MR1scFv are smaller and may penetrate
tumors better. Pseudomonas exotoxin PE38KDEL was modified to remove the natural cell
binding domain.;
Molecule name : MR1-1;
NCI Metathesaurus CUI : CL413562;
Origin ID : C88307;
UMLS CUI : C2981823;
Semantic type(s)
- concept_is_in_subset
- has_target
