Preferred Label : pNGVL4a-CRT/E7(detox) DNA Vaccine;
NCIt definition : A cancer vaccine consisting of the DNA plasmid pNGVL4a-A encoding calreticulin (CRT)
linked to a detox form of human papillomavirus (HPV) type 16 E7 antigen, with potential
immunomodulating and antineoplastic activities. Upon administration, this vaccine
may generate a potent cytotoxic T-lymphocyte (CTL) response against E7-expressing
tumor cells, resulting in tumor cell death. For E7(detox), the amino acids in E7 at
positions 24 (cysteine to glycine) and 26 (glutamic acid to glycine) were substituted.
CRT, a 46 kDa protein located in the lumen of the cell's endoplasmic reticulum (ER),
may potentiate MHC class I presentation of HPV-16 E7 to E7-specific CD8-positive T
cells. In addition, pNGVL4a-A contains two short immunostimulatory DNA sequences (ISS)
in the noncoding region, which may elicit the production of IFN- and IL-12 in transfected
keratinocytes and dermal antigen presenting cells (APCs), resulting in a potent T
helper cell type 1 response.;
NCI Metathesaurus CUI : CL413538;
Origin ID : C88289;
UMLS CUI : C2981811;
Semantic type(s)
- concept_is_in_subset
- has_target
