Preferred Label : Anti-CD45 BC8 Monoclonal Antibody-Streptavidin Conjugate;
NCIt synonyms : Anti-CD45 BC8 Antibody-Streptavidin Fusion Protein; BC8 scFv4SA Fusion Protein;
NCIt definition : An immunoconjugate containing a monoclonal antibody directed against the CD45 antigen
BC8, conjugated to streptavidin, a nonglycosylated homotetrameric protein that has
four high affinity binding sites for biotin. Anti-CD45 BC8 antibody-streptavidin conjugate
binds to CD45, a transmembrane protein tyrosine phosphatase that is expressed on the
surface of normal and malignant hematopoietic cells. Upon administration of a biotin-based
radioconjugate, the biotin moiety of the radioconjugate binds to the streptavidin
moiety of anti-CD45 BC8 antibody-streptavidin conjugate and, upon cellular internalization,
specifically delivers cytotoxic radiation to CD45-expressing tumor cells.;
NCI Metathesaurus CUI : CL413536;
Origin ID : C88287;
UMLS CUI : C2981809;
Semantic type(s)
- concept_is_in_subset
