Preferred Label : Pegylated Recombinant Human Arginase I BCT-100;
NCIt synonyms : rhArgIpeg5000; RH-ARG1-PEG-5,000 MW;
NCIt related terms : BCT-100;
NCIt definition : A recombinant human arginase I (liver arginase) covalently attached, via a succinamide
propionic acid (SPA) linker, to a polyethylene glycol (PEG) of molecular weight 5,000
[rhArg-peg(5,000mw)] with potential antineoplastic activity. Upon intravenous administration
of pegylated recombinant human arginase I BCT-100, arginase metabolizes the amino
acid arginine to ornithine and urea, depleting intracellular arginine, which may inhibit
proliferation of cells that are auxotrophic for arginine such as hepatocellular carcinoma
(HCC) cells. This agent may also work synergistically with various cytotoxic agents.;
UNII : S3HC6XX81X;
CAS number : 1433787-75-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1433787-75-7
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G-SRS /a ;
Molecule name : BCT-100;
NCI Metathesaurus CUI : CL413535;
Origin ID : C88286;
UMLS CUI : C2981808;
Semantic type(s)
- UMLS correspondences (same concept)
- BCT-100 [MeSH Supplementary Concept]
- concept_is_in_subset
