Preferred Label : Iodine I-124 FIAU;
NCIt synonyms : 124I-2-Fluoro-2-deoxy-5-[124I]iodo-1beta-d-arabinofuranosyluracil; 124I-FIAU;
NCIt related terms : FIALURIDINE I-124;
NCIt definition : A radioconjugate containing the nucleoside analog 2'-fluoro-2'-deoxy-1beta-D-arabinofuranosyl-5-iodouracil
(FIAU) labeled with the radioisotope iodine I 124 with positron-emitting activity.
Chemotherapeutic agents such as bortezomib may induce viral thymidine kinase expression
in EBV- and Kaposi's sarcoma herpesvirus (KSHV)-associated tumors. Subsequent to chemotherapy
induction of viral TK in these tumors, administered iodine I 124 FIAU is phosphorylated
by expressed viral TK, becoming selectively trapped within TK-expressing tumor cells;
these cells can then be visualized with positron emission tomography (PET). Viral
TK is either not expressed or is expressed at very low levels in EBV- and Kaposi's
sarcoma herpesvirus (KSHV)-associated tumors and may be activated by certain chemotherapeutic
agents.;
UNII : 726X882183;
CAS number : 183293-72-3;
NCI Metathesaurus CUI : CL413534;
Origin ID : C88284;
UMLS CUI : C2981807;
Semantic type(s)
- concept_is_in_subset
