Necitumumab - CISMeF

Preferred Label : Necitumumab;

NCIt synonyms : Anti-Epidermal Growth Factor Receptor Monoclonal Antibody IMC-11F8; Immunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor (Receptor Tyrosine-Protein Kinase ErbB-1, EC 2.7.10.1)); Human Monoclonal IMC-11F8 Gamma1 Heavy Chain (224-214')-Disulfide with Human Monoclonal IMC-11F8 Kappa Light Chain, Dimer (230- 230'':233-233'')-Bisdisulfide;

NCIt definition : A fully human IgG1 monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Necitumumab binds to and blocks the ligand binding site of EGFR, thereby preventing the activation and subsequent dimerization of the receptor. This may lead to an inhibition of EGFR-dependent downstream pathways and so inhibition of EGFR-dependent tumor cell proliferation and metastasis. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of various tumor cell types.;

UNII : 2BT4C47RUI;

CAS number : 906805-06-9;

Drug name : Portrazza;

Molecule name : IMC-11F8; IMC 11F8;

Codes from synonyms : 347;

Details

Origin ID

C88281;

UMLS CUI

C2352806;

Automatic exact mappings (from CISMeF team)
- Necitumumab [ICD-11 Extension code]
CISMeF manual mappings
- Necitumumab (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- necitumumab [MeSH concept]
- necitumumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing necitumumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Necitumumab (substance) [SNOMED CT concept]
- Product containing necitumumab (medicinal product) [SNOMED CT concept]
- necitumumab [ATC Code]
- necitumumab [MeSH concept]
- necitumumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- necitumumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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